Editor’s Highlight: Collaborative Cross Mouse Population Enables Refinements to Characterization of the Variability in Toxicokinetics of Trichloroethylene and Provides Genetic Evidence for the Role of PPAR Pathway in Its Oxidative Metabolism

BACKGROUND: Trichloroethylene (TCE) is a known carcinogen in humans and rodents. Previous studies of inter-strain variability in TCE metabolism were conducted in multi-strain panels of classical inbred mice with limited genetic diversity to identify gene-environment interactions associated with chem...

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Vydáno v:Toxicol Sci
Hlavní autoři: Venkatratnam, Abhishek, Furuya, Shinji, Kosyk, Oksana, Gold, Avram, Bodnar, Wanda, Konganti, Kranti, Threadgill, David W., Gillespie, Kevin M., Aylor, David L., Wright, Fred A., Chiu, Weihsueh A., Rusyn, Ivan
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
Témata:
Revealing Role of PPAR in Trichloroethylene Toxicity Using the Collaborative Cross
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6075464/
https://ncbi.nlm.nih.gov/pubmed/28369613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfx065
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