Small interfering RNA-mediated control of virus replication in the CNS is therapeutic and enables natural immunity to West Nile virus

No vaccines or therapeutics are licensed for West Nile virus (WNV), a mosquito-transmitted neuroencephalitic flavivirus. The siRNA, siFvE(JW), targets a conserved sequence within the WNV E protein and limits virus infection. Using a Rabies virus-derived neuron-targeting peptide (RVG9R) and an intran...

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Udgivet i:Cell Host Microbe
Main Authors: Beloor, Jagadish, Maes, Nyree, Ullah, Irfan, Uchil, Pradeep, Jackson, Andrew, Fikrig, Erol, Lee, Sang Kyung, Kumar, Priti
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6074029/
https://ncbi.nlm.nih.gov/pubmed/29606496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2018.03.001
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