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Small interfering RNA-mediated control of virus replication in the CNS is therapeutic and enables natural immunity to West Nile virus
No vaccines or therapeutics are licensed for West Nile virus (WNV), a mosquito-transmitted neuroencephalitic flavivirus. The siRNA, siFvE(JW), targets a conserved sequence within the WNV E protein and limits virus infection. Using a Rabies virus-derived neuron-targeting peptide (RVG9R) and an intran...
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| Publicado no: | Cell Host Microbe |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6074029/ https://ncbi.nlm.nih.gov/pubmed/29606496 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2018.03.001 |
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