The Curcumin Analog CH-5 Exerts Anticancer Effects in Human Osteosarcoma Cells via Modulation of Transcription Factors p53/Sp1

Curcumin is a potential anticancer drug with poor bioavailability, which limits its clinical use as a therapeutic agent. The aim of this study was a preliminary evaluation of the curcumin analogue CH-5 as a cytotoxic agent in human osteosarcoma cell lines U2OS, MG-63, and Saos-2. CH-5 inhibited cell...

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Détails bibliographiques
Publié dans:Int J Mol Sci
Auteurs principaux: Lima, Felipe Teixeira, Seba, Viviane, Silva, Gabriel, Torrezan, Guilherme Silva, Polaquini, Carlos Roberto, Pinhanelli, Vitor Caressato, Baek, Seung J., Fachin, Ana Lúcia, Regasini, Luis Octavio, Marins, Mozart
Format: Artigo
Langue:Inglês
Publié: MDPI 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6073932/
https://ncbi.nlm.nih.gov/pubmed/29966255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19071909
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