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Multi-Acting Mitochondria-Targeted Platinum(IV) Prodrugs of Kiteplatin with α-Lipoic Acid in the Axial Positions

Platinum(II) drugs are activated intracellularly by aquation of the leaving groups and then bind to DNA, forming DNA adducts capable to activate various signal-transduction pathways. Mostly explored in recent years are Pt(IV) complexes which allow the presence of two additional ligands in the axial...

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Bibliografiske detaljer
Udgivet i:Int J Mol Sci
Main Authors: Savino, Salvatore, Marzano, Cristina, Gandin, Valentina, Hoeschele, James D., Natile, Giovanni, Margiotta, Nicola
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6073472/
https://ncbi.nlm.nih.gov/pubmed/30011897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19072050
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