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Homozygous missense MYBPC3 Pro873His mutation associated with increased risk for heart failure development in hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy (HCM) is a primary autosomal‐dominant disorder of the myocardium with variable expressivity and penetrance. Occasionally, homozygous sarcomere genetic variants emerge while genotyping HCM patients. In these cases, a more severe HCM phenotype is generally seen. Here, we re...

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Detalhes bibliográficos
Publicado no:ESC Heart Fail
Main Authors: Kissopoulou, Antheia, Trinks, Cecilia, Green, Anna, Karlsson, Jan‐Erik, Jonasson, Jon, Gunnarsson, Cecilia
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6073032/
https://ncbi.nlm.nih.gov/pubmed/29663722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ehf2.12288
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