Human Plasmablast Migration Toward CXCL12 Requires Glucose Oxidation by Enhanced Pyruvate Dehydrogenase Activity via AKT

Migration of human plasmablast to the bone marrow is essential for the final differentiation of plasma cells and maintenance of effective humoral immunity. This migration is controlled by CXCL12/CXCR4-mediated activation of the protein kinase AKT. Herein, we show that the CXCL12-induced migration of...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Immunol
Prif Awduron: Pak, Hyo-Kyung, Nam, Bora, Lee, Yoon Kyoung, Kim, Yong-Woo, Roh, Jin, Son, Jaekyoung, Chung, Yoo-Sam, Choe, Jongseon, Park, Chan-Sik
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2018
Pynciau:
Immunology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072847/
https://ncbi.nlm.nih.gov/pubmed/30100910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01742
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