TNF-α increases the intrinsic excitability of cerebellar Purkinje cells through elevating glutamate release in Bergmann Glia

For decades, the glial function has been highlighted not only as the ‘structural glue’, but also as an ‘active participant’ in neural circuits. Here, we suggest that tumor necrosis factor α (TNF-α), a key inflammatory cytokine, alters the neural activity of the cerebellar Purkinje cells (PCs) by fac...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Shim, Hyun Geun, Jang, Sung-Soo, Kim, Seung Ha, Hwang, Eun Mi, Min, Joo Ok, Kim, Hye Yun, Kim, Yoo Sung, Ryu, Changhyeon, Chung, Geehoon, Kim, YoungSoo, Yoon, Bo-Eun, Kim, Sang Jeong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072779/
https://ncbi.nlm.nih.gov/pubmed/30072733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-29786-9
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