Mitochondria-targeted betulinic and ursolic acid derivatives: synthesis and anticancer activity

A series of new betulinic and ursolic acid conjugates with a lipophilic triphenylphosphonium cation, meant to enhance the bioavailability and mitochondriotropic action of natural triterpenes, have been synthesized. The in vitro experiments on three human cancer cell lines (MCF-7, HCT-116 and TET21N)...

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Bibliographic Details
Published in:Medchemcomm
Main Authors: Nedopekina, Darya A., Gubaidullin, Rinat R., Odinokov, Victor N., Maximchik, Polina V., Zhivotovsky, Boris, Bel'skii, Yuriy P., Khazanov, Veniamin A., Manuylova, Arina V., Gogvadze, Vladimir, Spivak, Anna Yu.
Format: Artigo
Language:Inglês
Published: Royal Society of Chemistry 2017
Subjects:
Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072465/
https://ncbi.nlm.nih.gov/pubmed/30108714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00248c
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