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The molecular basis of the interactions between synthetic retinoic acid analogues and the retinoic acid receptors

All-trans-retinoic acid (ATRA) and its synthetic analogues EC23 and EC19 direct cellular differentiation by interacting as ligands for the retinoic acid receptor (RARα, β and γ) family of nuclear receptor proteins. To date, a number of crystal structures of natural and synthetic ligands complexed to...

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Détails bibliographiques
Publié dans:Medchemcomm
Auteurs principaux: Haffez, Hesham, Chisholm, David R., Valentine, Roy, Pohl, Ehmke, Redfern, Christopher, Whiting, Andrew
Format: Artigo
Langue:Inglês
Publié: Royal Society of Chemistry 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072416/
https://ncbi.nlm.nih.gov/pubmed/30108774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6md00680a
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