Probing biological activity through structural modelling of ligand-receptor interactions of 2,4-disubstituted thiazole retinoids

Retinoids, such as all-trans-retinoic acid (ATRA), regulate cellular differentiation and signalling pathways in chordates by binding to nuclear retinoic acid receptors (RARα/β/γ). Polar interactions between receptor and ligand are important for binding and facilitating the non-polar interactions and...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Bioorg Med Chem
Prif Awduron: Haffez, Hesham, Chisholm, David R., Tatum, Natalie J., Valentine, Roy, Redfern, Christopher, Pohl, Ehmke, Whiting, Andrew, Przyborski, Stefan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier Science 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5933457/
https://ncbi.nlm.nih.gov/pubmed/29439915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2018.02.002
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg