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Probing biological activity through structural modelling of ligand-receptor interactions of 2,4-disubstituted thiazole retinoids
Retinoids, such as all-trans-retinoic acid (ATRA), regulate cellular differentiation and signalling pathways in chordates by binding to nuclear retinoic acid receptors (RARα/β/γ). Polar interactions between receptor and ligand are important for binding and facilitating the non-polar interactions and...
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| Publicado no: | Bioorg Med Chem |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier Science
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5933457/ https://ncbi.nlm.nih.gov/pubmed/29439915 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2018.02.002 |
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