Synthesis and evaluation of nuciferine and roemerine enantiomers as 5-HT(2) and α(1) receptor antagonists

In this study, the (S)-enantiomers of the aporphine alkaloids, nuciferine and roemerine, were prepared via a synthetic route involving catalytic asymmetric hydrogenation and both stereoisomers were evaluated in vitro for functional activity at human 5-HT(2) and adrenergic α(1) receptor subtypes usin...

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Опубликовано в: :Medchemcomm
Главные авторы: Heng, Hui Li, Chee, Chin Fei, Chin, Sek Peng, Ouyang, Yifan, Wang, Hao, Buckle, Michael J. C., Herr, Deron R., Paterson, Ian C., Doughty, Stephen W., Abd. Rahman, Noorsaadah, Chung, Lip Yong
Формат: Artigo
Язык:Inglês
Опубликовано: Royal Society of Chemistry 2018
Предметы:
Chemistry
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072365/
https://ncbi.nlm.nih.gov/pubmed/30108948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00629b
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