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Designing safer oral drugs

Designing an oral drug such that its estimated dose to humans is both efficacious and safe is challenging. During the early design stage, where in vitro or preclinical species in vivo safety data are limited, heuristic-based criteria often related to physicochemical properties are used for guidance....

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Medchemcomm
Glavni avtor: Wenlock, M. C.
Format: Artigo
Jezik:Inglês
Izdano: Royal Society of Chemistry 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072361/
https://ncbi.nlm.nih.gov/pubmed/30108773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6md00706f
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