Sclerostin is upregulated in the early stage of chondrogenic differentiation, but not required in endochondral ossification in vitro

Sclerostin is a potent inhibitor of the canonical Wnt signaling pathway. Wnt signaling pathways have multiple roles in the regulation of cartilage development, growth, and maintenance. This study focused on the role of sclerostin in the process of chondrogenic differentiation. We hypothesized that s...

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Veröffentlicht in:PLoS One
Hauptverfasser: Yamaguchi, Yasuteru, Kumagai, Ken, Imai, Sosuke, Miyatake, Kazuma, Saito, Tomoyuki
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072128/
https://ncbi.nlm.nih.gov/pubmed/30071108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0201839
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