Distinct regions of the intrinsically disordered protein MUT-16 mediate assembly of a small RNA amplification complex and promote phase separation of Mutator foci

In C. elegans, efficient RNA silencing requires small RNA amplification mediated by RNA-dependent RNA polymerases (RdRPs). RRF-1, an RdRP, and other Mutator complex proteins localize to Mutator foci, which are perinuclear germline foci that associate with nuclear pores and P granules to facilitate s...

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Publicat a:PLoS Genet
Autors principals: Uebel, Celja J., Anderson, Dorian C., Mandarino, Lisa M., Manage, Kevin I., Aynaszyan, Stephan, Phillips, Carolyn M.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072111/
https://ncbi.nlm.nih.gov/pubmed/30036386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007542
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