Design, synthesis and bioactivity investigation of tetrandrine derivatives as potential anti-cancer agents

Twenty-four 14-sulfonamide–tetrandrine derivatives as potential anti-cancer agents were synthesized. The synthetic derivatives were investigated for their cytotoxic activity against human cancer cell lines MDA-MB-231, PC3, WM9, HEL and K562. Initially, the IC(50) values (50% inhibitory concentration...

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Vydáno v:Medchemcomm
Hlavní autoři: Song, Junrong, Lan, Junjie, Chen, Chao, Hu, Shengcao, Song, Jialei, Liu, Wulin, Zeng, Xueyi, Lou, Huayong, Ben-David, Yaacov, Pan, Weidong
Médium: Artigo
Jazyk:Inglês
Vydáno: Royal Society of Chemistry 2018
Témata:
Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072089/
https://ncbi.nlm.nih.gov/pubmed/30109000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00125a
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