Discovery of indoleamine 2,3-dioxygenase inhibitors using machine learning based virtual screening

Indoleamine 2,3-dioxygenase (IDO), an immune checkpoint, is a promising target for cancer immunotherapy. However, current IDO inhibitors are not approved for clinical use yet; therefore, new IDO inhibitors are still demanded. To identify new IDO inhibitors, we have built naive Bayesian (NB) and recu...

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Detalhes bibliográficos
Publicado no:Medchemcomm
Main Authors: Zhang, Hongao, Liu, Wei, Liu, Zhihong, Ju, Yingchen, Xu, Mengyang, Zhang, Yue, Wu, Xinyu, Gu, Qiong, Wang, Zhong, Xu, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2018
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071933/
https://ncbi.nlm.nih.gov/pubmed/30108982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00642j
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