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Membrane activity profiling of small molecule B. subtilis growth inhibitors utilizing novel duel-dye fluorescence assay

Small molecule disruption of the bacterial membrane is both a challenge and interest for drug development. While some avoid membrane activity due to toxicity issues, others are interested in leveraging the effects for new treatments. Existing assays are available for measuring disruption of membrane...

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Detalhes bibliográficos
Publicado no:Medchemcomm
Main Authors: McAuley, S., Huynh, A., Czarny, T. L., Brown, E. D., Nodwell, J. R.
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071753/
https://ncbi.nlm.nih.gov/pubmed/30108946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00009c
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