Development of a peptide-based bifunctional chelator conjugated to a cytotoxic drug for the treatment of melanotic melanoma

The cytotoxic drug gemcitabine (GEM) has been conjugated to receptor-binding peptides to target melanoma tumors. A hexapeptide having a Lys–Gly–His–Lys sequence (pep-1), an octapeptide with an Arg–Gly–Asp–Lys–Gly–His–Lys sequence (pep-2), a GEM-conjugated Lys–Gly–His–Lys peptide (GEM–pep-3) and a GE...

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Detalhes bibliográficos
Publicado no:Medchemcomm
Main Authors: Gaonkar, Raghuvir H., Baishya, Rinku, Paul, Brahamacharry, Dewanjee, Saikat, Ganguly, Shantanu, Debnath, Mita C., Ganguly, Soumya
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2018
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071751/
https://ncbi.nlm.nih.gov/pubmed/30108970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00638a
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