Identification of mitoxantrone as a new inhibitor of ROS1 fusion protein in non-small cell lung cancer cells

Mitoxantrone, an FDA-approved drug for multiple sclerosis and hormone refractory prostate cancer, is identified as a potent inhibitor of ROS1 fusion protein by in silico screening in non-small cell lung cancer cells. Mitoxantrone can suppress the phosphorylation of ROS1 and subsequently inhibit its...

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Udgivet i:Medchemcomm
Main Authors: Luo, Lian-Xiang, Fan, Xing-Xing, Li, Ying, Peng, Xia, Ji, Yin-Chun, Hsiao, Wendy Wen-Luan, Liu, Liang, Leung, Elaine Lai-Han, Yao, Xiao-Jun
Format: Artigo
Sprog:Inglês
Udgivet: Royal Society of Chemistry 2017
Fag:
Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071735/
https://ncbi.nlm.nih.gov/pubmed/30108778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6md00643d
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