Nano-delivery of fraxinellone remodels tumor microenvironment and facilitates therapeutic vaccination in desmoplastic melanoma

Rationale: Tumor-associated fibroblasts (TAFs) play a critical role in the suppressive immune tumor microenvironment (TME), compromising the efficacy of immunotherapy. To overcome this therapeutic hurdle, we developed a nanoemulsion (NE) formulation to deliver fraxinellone (Frax), an anti-fibrotic m...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Hou, Lin, Liu, Qi, Shen, Limei, Liu, Yun, Zhang, Xueqiong, Chen, Fengqian, Huang, Leaf
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071534/
https://ncbi.nlm.nih.gov/pubmed/30083259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.24821
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