Heterologous Biosynthesis, Modifications and Structural Characterization of Ruminococcin-A, a Lanthipeptide From the Gut Bacterium Ruminococcus gnavus E1, in Escherichia coli

Ruminococcin A (RumA) is a lanthipeptide with high activity against pathogenic clostridia and is naturally produced by the strict anaerobic bacterium Ruminococcus gnavus E1, isolated from human intestine. Cultivating R. gnavus E1 is challenging, limiting high-quality production, further biotechnolog...

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Bibliographic Details
Published in:Front Microbiol
Main Authors: Ongey, Elvis L., Giessmann, Robert T., Fons, Michel, Rappsilber, Juri, Adrian, Lorenz, Neubauer, Peter
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Microbiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071512/
https://ncbi.nlm.nih.gov/pubmed/30093894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2018.01688
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