Modified Release Itraconazole Amorphous Solid Dispersion to Treat Aspergillus fumigatus: Importance of the Animal Model Selection

Previously, modified release itraconazole in the form of a melt-extruded amorphous solid dispersion based on a pH dependent enteric polymer combined with hydrophilic additives (HME-ITZ), exhibited improved in vitro dissolution properties. These properties agreed with pharmacokinetic results in rats...

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Detalhes bibliográficos
Publicado no:Drug Dev Ind Pharm
Main Authors: Maincent, Julien, Najvar, Laura K., Kirkpatrick, William R., Huang, Siyuan, Patterson, Thomas F., Wiederhold, Nathan P., Peters, Jay I., Williams, Robert O.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6069995/
https://ncbi.nlm.nih.gov/pubmed/27645428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/03639045.2016.1236811
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