Osteopontin alters DNA methylation through up-regulating DNMT1 and sensitizes CD133+/CD44+ cancer stem cells to 5 azacytidine in hepatocellular carcinoma

BACKGROUND: In hepatocellular carcinoma (HCC), CD133+/CD44+ cells are one subgroup with high stemness and responsible for metastatic relapse and resistance to treatment. Our previous studies have demonstrated that osteopontin (OPN) plays critical roles in HCC metastasis. We further investigated the...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Exp Clin Cancer Res
Prif Awduron: Gao, Xiaomei, Sheng, Yuanyuan, Yang, Jing, Wang, Chaoqun, Zhang, Rui, Zhu, Ying, Zhang, Ze, Zhang, Kaili, Yan, Shican, Sun, Haoting, Wei, Jinwang, Wang, Xuan, Yu, Xinxin, Zhang, Yu, Luo, Qin, Zheng, Yan, Qiao, Peng, Zhao, Yue, Dong, Qiongzhu, Qin, Lunxiu
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2018
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6069805/
https://ncbi.nlm.nih.gov/pubmed/30064482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0832-1
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