Osteopontin alters DNA methylation through up-regulating DNMT1 and sensitizes CD133+/CD44+ cancer stem cells to 5 azacytidine in hepatocellular carcinoma

BACKGROUND: In hepatocellular carcinoma (HCC), CD133+/CD44+ cells are one subgroup with high stemness and responsible for metastatic relapse and resistance to treatment. Our previous studies have demonstrated that osteopontin (OPN) plays critical roles in HCC metastasis. We further investigated the...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Exp Clin Cancer Res
Egile Nagusiak: Gao, Xiaomei, Sheng, Yuanyuan, Yang, Jing, Wang, Chaoqun, Zhang, Rui, Zhu, Ying, Zhang, Ze, Zhang, Kaili, Yan, Shican, Sun, Haoting, Wei, Jinwang, Wang, Xuan, Yu, Xinxin, Zhang, Yu, Luo, Qin, Zheng, Yan, Qiao, Peng, Zhao, Yue, Dong, Qiongzhu, Qin, Lunxiu
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2018
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6069805/
https://ncbi.nlm.nih.gov/pubmed/30064482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0832-1
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak