Pharmacological postconditioning with Neuregulin-1 mimics the cardioprotective effects of ischaemic postconditioning via ErbB4-dependent activation of reperfusion injury salvage kinase pathway

BACKGROUND: The protective effect of Neuregulin-1 (NRG-1) on heart failure is well established. In this study, we assessed whether NRG-1 could protect the heart by mimicking the cardioprotective effects of ischaemic postconditioning (IP). METHODS: We used a myocardial reperfusion injury rat model in...

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Detalhes bibliográficos
Publicado no:Mol Med
Main Authors: Wang, Fuhua, Wang, Huan, Liu, Xuejing, Yu, Haiyi, Zuo, Bo, Song, Zhu, Wang, Ning, Huang, Wei, Wang, Guisong
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6069706/
https://ncbi.nlm.nih.gov/pubmed/30134819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s10020-018-0040-7
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