Neuregulin‐1 alleviate oxidative stress and mitigate inflammation by suppressing NOX4 and NLRP3/caspase‐1 in myocardial ischaemia‐reperfusion injury

Neuregulin‐1 (NRG‐1) is reported to be cardioprotective through the extracellular‐regulated protein kinase (ERK) 1/2 pathway in myocardial ischaemia‐reperfusion injury (MIRI). NOX4‐induced ROS activated NLRP3 inflammasome and exacerbates MIRI. This study aims to investigate whether NRG‐1 can suppres...

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Publicado en:J Cell Mol Med
Main Authors: Wang, Fuhua, Wang, Huan, Liu, Xuejing, Yu, Haiyi, Huang, Xiaomin, Huang, Wei, Wang, Guisong
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2021
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7875921/
https://ncbi.nlm.nih.gov/pubmed/33470533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.16287
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