Image-Guided Development of Heterocyclic Sulfoxides as Ligands for Tau Neurofibrillary Tangles: From First-in-Man to Second-Generation Ligands

[Image: see text] Positron emission tomography (PET) imaging of misfolded protein aggregates that form in neurodegenerative processes of the brain is key to providing a robust marker for improved diagnosis and evaluation of treatments. We report the development of advanced radiotracer candidates bas...

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Publicat a:ACS Omega
Autors principals: Rafique, Waqas, Kramer, Vasko, Pardo, Tania, Smits, René, Spilhaug, Mona M., Hoepping, Alexander, Savio, Eduardo, Engler, Henry, Kuljs, Rodrigo, Amaral, Horacio, Riss, Patrick J.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2018
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6068598/
https://ncbi.nlm.nih.gov/pubmed/30087917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.8b00975
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