Early Axonopathy Preceding Neurofibrillary Tangles in Mutant Tau Transgenic Mice

Neurodegenerative diseases characterized by brain and spinal cord involvement often show widespread accumulations of tau aggregates. We have generated a transgenic mouse line (Tg30tau) expressing in the forebrain and the spinal cord a human tau protein bearing two pathogenic mutations (P301S and G27...

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Detalhes bibliográficos
Main Authors: Leroy, Karelle, Bretteville, Alexis, Schindowski, Katharina, Gilissen, Emmanuel, Authelet, Michèle, De Decker, Robert, Yilmaz, Zehra, Buée, Luc, Brion, Jean-Pierre
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2007
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1959508/
https://ncbi.nlm.nih.gov/pubmed/17690183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.070345
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