Loss of androgen receptor signaling in prostate cancer‐associated fibroblasts (CAFs) promotes CCL2‐ and CXCL8‐mediated cancer cell migration

Fibroblasts are abundantly present in the prostate tumor microenvironment (TME), including cancer‐associated fibroblasts (CAFs) which play a key role in cancer development. Androgen receptor (AR) signaling is the main driver of prostate cancer (PCa) progression, and stromal cells in the TME also exp...

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Publicado en:Mol Oncol
Autores principales: Cioni, Bianca, Nevedomskaya, Ekaterina, Melis, Monique H. M., van Burgsteden, Johan, Stelloo, Suzan, Hodel, Emma, Spinozzi, Daniele, de Jong, Jeroen, van der Poel, Henk, de Boer, Jan Paul, Wessels, Lodewyk F. A., Zwart, Wilbert, Bergman, Andries M.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6068356/
https://ncbi.nlm.nih.gov/pubmed/29808619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12327
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