Loss of androgen receptor signaling in prostate cancer‐associated fibroblasts (CAFs) promotes CCL2‐ and CXCL8‐mediated cancer cell migration

Fibroblasts are abundantly present in the prostate tumor microenvironment (TME), including cancer‐associated fibroblasts (CAFs) which play a key role in cancer development. Androgen receptor (AR) signaling is the main driver of prostate cancer (PCa) progression, and stromal cells in the TME also exp...

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Publicat a:Mol Oncol
Autors principals: Cioni, Bianca, Nevedomskaya, Ekaterina, Melis, Monique H. M., van Burgsteden, Johan, Stelloo, Suzan, Hodel, Emma, Spinozzi, Daniele, de Jong, Jeroen, van der Poel, Henk, de Boer, Jan Paul, Wessels, Lodewyk F. A., Zwart, Wilbert, Bergman, Andries M.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2018
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6068356/
https://ncbi.nlm.nih.gov/pubmed/29808619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12327
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