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NMR measurements reveal the structural basis of transthyretin destabilization by pathogenic mutations
Inherited mutations of transthyretin (TTR) destabilize its structure, leading to aggregation and familial amyloid disease. Although numerous crystal structures of WT and mutant TTRs have been determined, they have failed to yield a comprehensive structural explanation for destabilization by pathogen...
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| Udgivet i: | Biochemistry |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6067956/ https://ncbi.nlm.nih.gov/pubmed/29972637 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00642 |
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