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Long term adaptation of a microbial population to a permanent metabolic constraint: overcoming thymineless death by experimental evolution of Escherichia coli

BACKGROUND: To maintain populations of microbial cells under controlled conditions of growth and environment for an indefinite duration is a prerequisite for experimentally evolving natural isolates of wild-type species or recombinant strains. This goal is beyond the scope of current continuous cult...

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Detalhes bibliográficos
Main Authors: de Crécy-Lagard, Valérie A, Bellalou, Jacques, Mutzel, Rupert, Marlière, Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC60676/
https://ncbi.nlm.nih.gov/pubmed/11737878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-1-10
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