Suppressing Nodal Signaling Activity Predisposes Ectodermal Differentiation of Epiblast Stem Cells

The molecular mechanism underpinning the specification of the ectoderm, a transient germ-layer tissue, during mouse gastrulation was examined here in a stem cell-based model. We captured a self-renewing cell population with enhanced ectoderm potency from mouse epiblast stem cells (EpiSCs) by suppres...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Liu, Chang, Wang, Ran, He, Zhisong, Osteil, Pierre, Wilkie, Emilie, Yang, Xianfa, Chen, Jun, Cui, Guizhong, Guo, Wenke, Chen, Yingying, Peng, Guangdun, Tam, Patrick P.L., Jing, Naihe
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6067151/
https://ncbi.nlm.nih.gov/pubmed/30008328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.05.019
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