PTAP motif duplication in the p6 Gag protein confers a replication advantage on HIV-1 subtype C

HIV-1 subtype C (HIV-1C) may duplicate longer amino acid stretches in the p6 Gag protein, leading to the creation of an additional Pro–Thr/Ser–Ala–Pro (PTAP) motif necessary for viral packaging. However, the biological significance of a duplication of the PTAP motif for HIV-1 replication and pathoge...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Sharma, Shilpee, Arunachalam, Prabhu S., Menon, Malini, Ragupathy, Viswanath, Satya, Ravi Vijaya, Jebaraj, Joshua, Aralaguppe, Shambhu Ganeshappa, Rao, Chaitra, Pal, Sreshtha, Saravanan, Shanmugam, Murugavel, Kailapuri G., Balakrishnan, Pachamuthu, Solomon, Suniti, Hewlett, Indira, Ranga, Udaykumar
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2018
Teme:
Microbiology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6066301/
https://ncbi.nlm.nih.gov/pubmed/29773649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.815829
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