PTAP motif duplication in the p6 Gag protein confers a replication advantage on HIV-1 subtype C

HIV-1 subtype C (HIV-1C) may duplicate longer amino acid stretches in the p6 Gag protein, leading to the creation of an additional Pro–Thr/Ser–Ala–Pro (PTAP) motif necessary for viral packaging. However, the biological significance of a duplication of the PTAP motif for HIV-1 replication and pathoge...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Sharma, Shilpee, Arunachalam, Prabhu S., Menon, Malini, Ragupathy, Viswanath, Satya, Ravi Vijaya, Jebaraj, Joshua, Aralaguppe, Shambhu Ganeshappa, Rao, Chaitra, Pal, Sreshtha, Saravanan, Shanmugam, Murugavel, Kailapuri G., Balakrishnan, Pachamuthu, Solomon, Suniti, Hewlett, Indira, Ranga, Udaykumar
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6066301/
https://ncbi.nlm.nih.gov/pubmed/29773649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.815829
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