Glycine N-methyltransferase deletion in mice diverts carbon flux from gluconeogenesis to pathways that utilize excess methionine cycle intermediates

Glycine N-methyltransferase (GNMT) is the most abundant liver methyltransferase regulating the availability of the biological methyl donor, S-adenosylmethionine (SAM). Moreover, GNMT has been identified to be down-regulated in hepatocellular carcinoma (HCC). Despite its role in regulating SAM levels...

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Vydáno v:J Biol Chem
Hlavní autoři: Hughey, Curtis C., Trefts, Elijah, Bracy, Deanna P., James, Freyja D., Donahue, E. Patrick, Wasserman, David H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6066300/
https://ncbi.nlm.nih.gov/pubmed/29891549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002568
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