Glycine N-methyltransferase deletion in mice diverts carbon flux from gluconeogenesis to pathways that utilize excess methionine cycle intermediates

Glycine N-methyltransferase (GNMT) is the most abundant liver methyltransferase regulating the availability of the biological methyl donor, S-adenosylmethionine (SAM). Moreover, GNMT has been identified to be down-regulated in hepatocellular carcinoma (HCC). Despite its role in regulating SAM levels...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Hughey, Curtis C., Trefts, Elijah, Bracy, Deanna P., James, Freyja D., Donahue, E. Patrick, Wasserman, David H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6066300/
https://ncbi.nlm.nih.gov/pubmed/29891549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002568
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