Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics

Esophageal adenocarcinoma (EAC) incidence is increasing while 5-year survival rates remain less than 15%. A lack of experimental models has hampered progress. We have generated clinically annotated EAC organoid cultures that recapitulate the morphology, genomic, and transcriptomic landscape of the p...

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izdano v:Nat Commun
Main Authors: Li, Xiaodun, Francies, Hayley E., Secrier, Maria, Perner, Juliane, Miremadi, Ahmad, Galeano-Dalmau, Núria, Barendt, William J., Letchford, Laura, Leyden, Genevieve M., Goffin, Emma K., Barthorpe, Andrew, Lightfoot, Howard, Chen, Elisabeth, Gilbert, James, Noorani, Ayesha, Devonshire, Ginny, Bower, Lawrence, Grantham, Amber, MacRae, Shona, Grehan, Nicola, Wedge, David C., Fitzgerald, Rebecca C., Garnett, Mathew J.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6065407/
https://ncbi.nlm.nih.gov/pubmed/30061675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05190-9
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