High glucose reduces megalin-mediated albumin endocytosis in renal proximal tubule cells through protein kinase B O-GlcNAcylation

The role of albumin reabsorption in proximal tubule (PT) cells has emerged as an important factor in the genesis of albuminuria observed in the early stages of diabetes. Evidence has shown that a decrease in megalin expression could be the key mechanism in this process. In the present work, we inves...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Peruchetti, Diogo de Barros, Silva-Aguiar, Rodrigo Pacheco, Siqueira, Gabriela Marques, Dias, Wagner Barbosa, Caruso-Neves, Celso
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2018
Pynciau:
Signal Transduction
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6065196/
https://ncbi.nlm.nih.gov/pubmed/29871929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001337
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