Lupus nephritis: low urinary DNase I levels reflect loss of renal DNase I and may be utilized as a biomarker of disease progression

Renal DNase I is lost in advanced stages of lupus nephritis. Here, we determined if loss of renal DNase I reflects a concurrent loss of urinary DNase I, and whether absence of urinary DNase I predicts disease progression. Mouse and human DNase I protein and DNase I endonuclease activity levels were...

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Detalhes bibliográficos
Publicado no:J Pathol Clin Res
Main Authors: Pedersen, Hege L, Horvei, Kjersti D, Thiyagarajan, Dhivya, Norby, Gudrun E, Seredkina, Natalya, Moroni, Gabriella, Eilertsen, Gro Ø, Holdaas, Hallvard, Strøm, Erik H, Bakland, Gunnstein, Meroni, Pier‐Luigi, Rekvig, Ole P
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6065113/
https://ncbi.nlm.nih.gov/pubmed/29624903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cjp2.99
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