Lupus nephritis progression in FcγRIIB(-/-)yaa mice is associated with early development of glomerular electron dense deposits and loss of renal DNase I in severe disease

FcγRIIB(-/-)yaa mice develop severe lupus glomerulonephritis due to lack of an inhibitory immune cell receptor combined with a Y-chromosome linked autoimmune accelerator mutation. In the present study, we have investigated nephritis development and progression in FcγRIIB(-/-)yaa mice to find shared...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Horvei, Kjersti Daae, Pedersen, Hege Lynum, Fismen, Silje, Thiyagarajan, Dhivya, Schneider, Andrea, Rekvig, Ole Petter, Winkler, Thomas H., Seredkina, Natalya
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5708736/
https://ncbi.nlm.nih.gov/pubmed/29190833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0188863
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