The Human FSGS-Causing ANLN R431C Mutation Induces Dysregulated PI3K/AKT/mTOR/Rac1 Signaling in Podocytes

BACKGROUND: We previously reported that mutations in the anillin (ANLN) gene cause familial forms of FSGS. ANLN is an F-actin binding protein that modulates podocyte cell motility and interacts with the phosphoinositide 3-kinase (PI3K) pathway through the slit diaphragm adaptor protein CD2-associate...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Hall, Gentzon, Lane, Brandon M., Khan, Kamal, Pediaditakis, Igor, Xiao, Jianqiu, Wu, Guanghong, Wang, Liming, Kovalik, Maria E., Chryst-Stangl, Megan, Davis, Erica E., Spurney, Robert F., Gbadegesin, Rasheed A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2018
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6065096/
https://ncbi.nlm.nih.gov/pubmed/30002222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2017121338
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