Role of sodium channel subtype in action potential generation by neocortical pyramidal neurons

Neocortical pyramidal neurons express several distinct subtypes of voltage-gated Na(+) channels. In mature cells, Na(v)1.6 is the dominant channel subtype in the axon initial segment (AIS) as well as in the nodes of Ranvier. Action potentials (APs) are initiated in the AIS, and it has been proposed...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Katz, Efrat, Stoler, Ohad, Scheller, Anja, Khrapunsky, Yana, Goebbels, Sandra, Kirchhoff, Frank, Gutnick, Michael J., Wolf, Fred, Fleidervish, Ilya A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6065046/
https://ncbi.nlm.nih.gov/pubmed/29991598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1720493115
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