α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies

α-Synuclein (α-Syn) aggregation, proceeding from oligomers to fibrils, is one central hallmark of neurodegeneration in synucleinopathies. α-Syn oligomers are toxic by triggering neurodegenerative processes in in vitro and in vivo models. However, the precise contribution of α-Syn oligomers to neurit...

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發表在:Proc Natl Acad Sci U S A
Main Authors: Prots, Iryna, Grosch, Janina, Brazdis, Razvan-Marius, Simmnacher, Katrin, Veber, Vanesa, Havlicek, Steven, Hannappel, Christian, Krach, Florian, Krumbiegel, Mandy, Schütz, Oliver, Reis, André, Wrasidlo, Wolfgang, Galasko, Douglas R., Groemer, Teja W., Masliah, Eliezer, Schlötzer-Schrehardt, Ursula, Xiang, Wei, Winkler, Jürgen, Winner, Beate
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2018
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6065020/
https://ncbi.nlm.nih.gov/pubmed/29991596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1713129115
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