Tumor Killing by CD4(+) T Cells Is Mediated via Induction of Inducible Nitric Oxide Synthase-Dependent Macrophage Cytotoxicity

CD4(+) T cells can induce potent anti-tumor immune responses. Due to the lack of MHC class II expression in most cancer cells, antigen recognition occurs indirectly via uptake and presentation on tumor-infiltrating antigen-presenting cells (APCs). Activation of the APCs can induce tumor rejection, b...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Fauskanger, Marte, Haabeth, Ole Audun Werner, Skjeldal, Frode Miltzow, Bogen, Bjarne, Tveita, Anders Aune
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6064871/
https://ncbi.nlm.nih.gov/pubmed/30083157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01684
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