How Do CD4(+) T Cells Detect and Eliminate Tumor Cells That Either Lack or Express MHC Class II Molecules?

CD4(+) T cells contribute to tumor eradication, even in the absence of CD8(+) T cells. Cytotoxic CD4(+) T cells can directly kill MHC class II positive tumor cells. More surprisingly, CD4(+) T cells can indirectly eliminate tumor cells that lack MHC class II expression. Here, we review the mechanism...

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Bibliografiske detaljer
Main Authors: Haabeth, Ole Audun Werner, Tveita, Anders Aune, Fauskanger, Marte, Schjesvold, Fredrik, Lorvik, Kristina Berg, Hofgaard, Peter O., Omholt, Hilde, Munthe, Ludvig A., Dembic, Zlatko, Corthay, Alexandre, Bogen, Bjarne
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2014
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3995058/
https://ncbi.nlm.nih.gov/pubmed/24782871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2014.00174
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