Intestine‐specific expression of human chimeric intestinal alkaline phosphatase attenuates Western diet‐induced barrier dysfunction and glucose intolerance

Intestinal epithelial cell derived alkaline phosphatase (IAP) dephosphorylates/detoxifies bacterial endotoxin lipopolysaccharide (LPS) in the gut lumen. We have earlier demonstrated that consumption of high‐fat high‐cholesterol containing western type‐diet (WD) significantly reduces IAP activity, in...

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Detalhes bibliográficos
Publicado no:Physiol Rep
Main Authors: Ghosh, Siddhartha S., He, Hongliang, Wang, Jing, Korzun, William, Yannie, Paul J., Ghosh, Shobha
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6064712/
https://ncbi.nlm.nih.gov/pubmed/30058275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.13790
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