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High collagen density augments mTOR-dependent cancer stem cells in ERα+ mammary carcinomas, and increases mTOR-independent lung metastases

Metastatic estrogen receptor alpha positive (ERα+) cancers account for most breast cancer mortality. Cancer stem cells (CSCs) and dense/stiff extracellular matrices are implicated in aggression and therapy resistance. We examined this interplay and response to mTOR inhibition using ERα+ adenocarcino...

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Sonraí Bibleagrafaíochta
Foilsithe in:Cancer Lett
Main Authors: Shea, Michael P., O’Leary, Kathleen A., Wegner, Kyle A., Vezina, Chad M., Schuler, Linda A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2018
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6064659/
https://ncbi.nlm.nih.gov/pubmed/29935374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2018.06.025
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