Immune checkpoint blockade restores HIV-specific CD4 T cell help for NK cells

Immune exhaustion is an important feature of chronic infections such as HIV and a barrier to effective immunity against cancer. This dysfunction is in part controlled by inhibitory immune checkpoints. Blockade of the PD-1 or IL-10 pathways can reinvigorate HIV-specific CD4 T cell function in vitro,...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Porichis, Filippos, Hart, Meghan G., Massa, Alexandra, Everett, Holly L., Morou, Antigoni, Richard, Jonathan, Brassard, Nathalie, Veillette, Maxime, Hassan, Muska, Le Ly, Ngoc, Routy, Jean-Pierre, Freeman, Gordon J., Dubé, Mathieu, Finzi, Andrés, Kaufmann, Daniel E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6064609/
https://ncbi.nlm.nih.gov/pubmed/29934472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1701551
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