Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis

Contact inhibition enables noncancerous cells to cease proliferation and growth when they contact each other. This characteristic is lost when cells undergo malignant transformation, leading to uncontrolled proliferation and solid tumor formation. Here we report that autophagy is compromised in cont...

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Vydáno v:Nat Commun
Hlavní autoři: Pavel, Mariana, Renna, Maurizio, Park, So Jung, Menzies, Fiona M., Ricketts, Thomas, Füllgrabe, Jens, Ashkenazi, Avraham, Frake, Rebecca A., Lombarte, Alejandro Carnicer, Bento, Carla F., Franze, Kristian, Rubinsztein, David C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6063886/
https://ncbi.nlm.nih.gov/pubmed/30054475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05388-x
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