Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis

Contact inhibition enables noncancerous cells to cease proliferation and growth when they contact each other. This characteristic is lost when cells undergo malignant transformation, leading to uncontrolled proliferation and solid tumor formation. Here we report that autophagy is compromised in cont...

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Foilsithe in:Nat Commun
Main Authors: Pavel, Mariana, Renna, Maurizio, Park, So Jung, Menzies, Fiona M., Ricketts, Thomas, Füllgrabe, Jens, Ashkenazi, Avraham, Frake, Rebecca A., Lombarte, Alejandro Carnicer, Bento, Carla F., Franze, Kristian, Rubinsztein, David C.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2018
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6063886/
https://ncbi.nlm.nih.gov/pubmed/30054475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05388-x
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